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Description
Human TrkB , His tagProduct Specification Species Human Synonyms GP145 TrkB (Trk B), Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin related kinase B, NTRK2 Accession Q16620 Amino Acid Sequence Protein sequence(Q16620, Trp230 His430, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | GP145-TrkB (Trk-B), Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B, NTRK2 |
| Accession | Q16620 |
| Amino Acid Sequence | Protein sequence(Q16620, Trp230-His430, with C-10*His) WDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:24kDa Actual: 35-45kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3). Although originally identified as an oncogenic fusion in 1982, only recently has there been a renewed interest in the Trk family as it relates to its role in human cancers because of the identification of NTRK1 (TrkA), NTRK2 (TrkB) and NTRK3 (TrkC) gene fusions and other oncogenic alterations in a number of tumor types. A number of Trk inhibitors are in clinical trials and have shown early promise in shrinking human tumors. TrkB and its ligand BDNF have been associated to both normal brain function and in the pathology and progression of Alzheimer’s disease (AD) and other neurodegenerative disorders.
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4.5 ★★★★★
Based on 181 reviews
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Product Reviews
★★★★★ 5
Fixed noisy and leaking power steering pump
My daughters 2008 Honda Accord 2.4L 4 cylinder that had a very noisy power steering pump which was also starting to leak. I was about to buy a new pump when I found out it might just be leaking from the hoses to the pump. I bought these O rings for the hose connections at the power steering pump, and spent 15 minutes replacing them. Pump is quiet again! The suction hose can develop a leak, letting air get into the pump which creates the loud noises.
This fix is all I needed, and was much cheaper and faster than replacing the power steering pump.
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Reviewed in the United States on March 10, 2026
★★★★★ 5
Perfect!
Fits exactly on my 2000 civic and I have not had any issues!
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Reviewed in the United States on February 18, 2026
★★★★★ 5
Good brand
They work good so far.
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Reviewed in the United States on March 4, 2026
★★★★★ 5
Perfect fit for 2004 Honda Element, Fixed leak!!
Perfect fit for 2004 Honda Element Dx. Fixed my power steering leak and was super easy to install. Took 5-10mins at most. Would definitely buy again, 5/5 stars!!!
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Reviewed in the United States on December 26, 2025
★★★★★ 5
Good fit
Both filters fit well on my 2019 Honda CRV. I was able to replace without struggle. Did it on my own first time.
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Reviewed in the United States on May 5, 2026