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Description
PD-L2/B7-DC His Tag Protein, MouseProduct Specification Species Mouse Synonyms PDL2, PD L2, Butyrophilin B7 DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2 Accession Q9WUL5 Amino Acid Sequence Leu20 Arg219, with C terminal 8*His LFTVTAPKEVYTVDVGSSVSLECDFDRRECTELEGIRASLQKVENDTSLQSERATLLEEQLPLGKALFHIPSVQVRDSGQYRCLVICGAAWDYKYLTVKVKASYMRIDTRILEVPGTGEVQLTCQARGYPLAEVSWQNVSVPANTSHIRTPEGLYQVTSVLRLKPQPSRNFSCMFWNAHMKELTSAIIDPLSRMEPKVPRGGGSHHHHHHHH Expression System HEK293 Molecular Weight 32 43kDa
Product Specification
| Species | Mouse |
| Synonyms | PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2 |
| Accession | Q9WUL5 |
| Amino Acid Sequence | Leu20-Arg219, with C-terminal 8*His LFTVTAPKEVYTVDVGSSVSLECDFDRRECTELEGIRASLQKVENDTSLQSERATLLEEQLPLGKALFHIPSVQVRDSGQYRCLVICGAAWDYKYLTVKVKASYMRIDTRILEVPGTGEVQLTCQARGYPLAEVSWQNVSVPANTSHIRTPEGLYQVTSVLRLKPQPSRNFSCMFWNAHMKELTSAIIDPLSRMEPKVPRGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 32-43kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Kojima M. et al. (2014) Fusion Protein of Mutant B7-DC and Fc Enhances the Antitumor Immune Effect of GM-CSF-secreting Whole-cell Vaccine. J Immunother. 37(3): 147-154. |
Background
B7-DC [also known as programmed death ligand 2 (PD-L2)] is a costimulatory molecule expressed predominantly on dendritic cells (DCs) and macrophages. In addition to its coinhibitory receptor, programmed death receptor 1 (PD-1), evidence suggests that B7-DC interacts with an unidentified costimulatory receptor on T cells. B7-DC mutants with selective binding capacity for the costimulatory receptor may be effective in stimulating antitumor immune responses, while avoiding the inhibitory effects of PD-1.
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4.3 ★★★★★
Based on 1167 reviews
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Product Reviews
★★★★★ 5
Best Dog Ball!!
Style: Ultra, Size: Small (2 Pack), Style: Ultra, Size: Small (2 Pack)
Our pug has been obsessed with this ball since we gave it to her — she even slept with it. Somehow it’s still in one piece, which never happens. Easily the best dog ball we’ve bought.
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Reviewed in the United States on May 18, 2026
★★★★★ 5
Difficult to destroy. Bounce really high.
Style: Squeaker, Size: Small (2 Pack)
Bought as a gift for a friend's small dog who dismantles tennis balls. He loves them. I have many years of experience with the product (in a larger size) for my big dog. He always had one either in his mouth or near him. They are pretty much indestructible.
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Reviewed in the United States on May 13, 2026
★★★★★ 4
High quality, wish it was just a little smaller
Style: Squeaker, Size: Small (2 Pack)
Love these. My dogs would play ball all day if I let them. These are very durable and bouncy. Love that it’s washable. They would chew up the small “tennis” balls to pieces so I love that they can’t destroy these. My only criticism is I wish these were just a little smaller (like the size of the small Kong tennis balls). My dogs can carry it in their tiny mouths but they can’t get their mouth around it enough to chew it to get the squeaker to squeak, which is their favorite thing.
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Reviewed in the United States on January 5, 2026
★★★★★ 5
Perfect for little dogs
Style: Ultra, Size: Small (2 Pack)
Perfect size for my 13 pound chihuahua mix. Great bounce and quality feel. Definitely worth it.
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Reviewed in the United States on March 26, 2026
★★★★★ 5
The perfect ball for a small to medium dog.
Style: Ultra, Size: Small (2 Pack)
My dog's favorite ball. Perfect size for playing catch and return for a small dog. She loves to chew on the ball. Very durable she has not been able to shred the ball.
A great entertainment value. This ball does not squeak.
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Reviewed in the United States on February 27, 2026