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Description
PD-L1 Recombinant Rat mAb, F(ab')₂ Fragment (SDT-R072)Product Specification Host Rat Antigen PD L1, F(AB') FRAGMENT Synonyms N A Immunogen N A Location Membrane Accession Q9EP73 Clone Number SDT R072 Antibody Type Recombinant mAb Isotype IgG2b Application SPR Reactivity Ms Purification Protein G Concentration N A Tag N A Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied Dilution application dilution species SPR
Product Specification
| Host | Rat |
| Antigen | PD-L1, F(AB')₂ FRAGMENT |
| Synonyms | N/A |
| Immunogen | N/A |
| Location | Membrane |
| Accession | Q9EP73 |
| Clone Number | SDT-R072 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG2b |
| Application | SPR |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | N/A |
| Tag | N/A |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| SPR | 125nM-1.95nM | null |
Background
Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the adaptive arm of immune systems during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. The binding of PD-L1 to the inhibitory checkpoint molecule PD-1 transmits an inhibitory signal based on interaction with phosphatases (SHP-1 or SHP-2) via Immunoreceptor Tyrosine-Based Switch Motif (ITSM). This reduces the proliferation of antigen-specific T-cells in lymph nodes, while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells) - further mediated by a lower regulation of the gene Bcl-2. Upregulation of PD-L1 on immune cells (especially myeloid cells) can also lead to formation of an immunosuppressive environment in a highly localized manner that also allow the cancer cells to proliferate.
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