MC5R Recombinant Rabbit mAb (S-3142-41)
SKU: 52782606401

MC5R Recombinant Rabbit mAb (S-3142-41)

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Description

MC5R Recombinant Rabbit mAb (S-3142-41)Product Specification Host Rabbit Antigen MC5R Synonyms Melanocortin receptor 5; MC5 R; MC 2 Immunogen Synthetic Peptide Location Cell membrane Accession P33032 Clone Number S 3142 41 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample K562, U 87 MG, HepG2, mouse brain, mouse testis, rat brain, rat testis Predicted Reactivity Cz Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical

Product Specification


Host Rabbit
Antigen MC5R
Synonyms Melanocortin receptor 5; MC5-R; MC-2
Immunogen Synthetic Peptide
Location Cell membrane
Accession P33032
Clone Number S-3142-41
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt
Positive Sample K562, U-87 MG, HepG2, mouse brain, mouse testis, rat brain, rat testis
Predicted Reactivity Cz
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt

Background

MC5R, a 325-amino-acid G-protein-coupled receptor encoded by MC5R on chromosome 18p11.2, is the most promiscuous of the five melanocortin receptors, binding α-, β- and γ-MSH as well as ACTH with nanomolar affinity to activate Gαs/cAMP signaling; it is highly expressed in sebaceous, lacrimal, meibomian and preputial glands, driving lipid-rich secretions that waterproof skin and hair, modulate thermoregulation, scent marking and innate immunity, and its global or sebocyte-specific deletion in mice produces a severe “dry coat” phenotype, altered sebum lipidomes, increased transepidermal water loss and susceptibility to dermatitis, while in humans MC5R polymorphisms correlate with acne severity and seborrheic dermatitis, making it a promising, highly tissue-restricted target for next-generation topical or systemic therapeutics aimed at controlling sebum output, dry eye, androgen-independent acne, and even metabolic syndrome through its recently discovered roles in adipose tissue lipolysis and hepatic steatosis.

Shipping Notes
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
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SKU: 52782606401

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4.4 ★★★★★
Based on 887 reviews
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Product Reviews
C
Verified Purchase
Crows Nest on The Sea
Lexington, US
★★★★★ 5
This is a big ball.
Larger than I thought but still a great toy for a heavy chew pup, easy to toss and won't go under funiture. She has the same ball in a 5 inch size so I know it's quality and will last. Can't wait for Summer, will make a great yard ball.
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Reviewed in the United States on March 22, 2026
J
Verified Purchase
Jason Twain
Waukegan, US
★★★★★ 5
Second one, first one lasted a good while
We leave it outside in the weather with solid results for our backyard dog, and the dog loves this thing. It's our go to toy for her, ... perfect for kick to fetch, tug of war, hide in the shirt, bump the human leg when it is wet, etc. ;) The first one we used and used and finally it started to show too much weathering, mildew, and finally breaking after like 1.5 years... we have extremely hot and wet weather here. When new though, these balls take a pounding. Our 50 pound dog can play tug of war to the extent we can pick her up while she holds onto the ball with her teeth. The ball doesn't flinch and the dog loves it. Kicking it is fun because you can give it a wallop and it won't go over the fence since the design absorbs a fair bit of the kick energy, but it is still enough for an adult or teen to send it about 1/4 an acre away. What else... oh the dog has a funny habit of finding the one spot that isn't an empty pentagon... as in the plastic is filled in there... and she likes to bit on that part especially during tug of war. I should also mention our dog literally breaks apart and sometimes eats sticks and twigs in the yard, can't be healthy, so a nice diversion is this ball that she will chew on once in a while without destroying it.
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Reviewed in the United States on July 10, 2022
C
Verified Purchase
CJ
Chelsea, US
★★★★★ 5
Absolutely love this brand of ball for my dog
I end up replacing these every couple years, yep that's right, years. My border collie will grab this ball in his mouth and then kick another ball around. Don't know why he has to have something in his mouth to play soccer, but he is unique. He managed to tear one of these up when he was in his teething stage, but it took him months, and I took it away as soon as he managed to remove a piece of it. Otherwise, we usually lose these much more often than them getting destroyed through constant chewing, and I suspect heavy weathering outside for an extended period of time. Nowadays he doesn't chew on rubber nearly that often, he has developed his own picky preferences. This ball is his must have for playing around. He loves to drop it down the stairs and play fetch with himself. It's easy for him to grab, it isn't heavy so we don't worry about furnishing, walls, or family members when he is tossing it around. It is much more durable than most, with the exception of really heavy chewers/teething, even then it held up for a long time. As long as you are careful to remove it if they manage to chew through I would even try it out with teething puppies. The lawnmower is also this balls nemesis, it loses every time. If only I could convince the dog that he needs to stop sacrificing toys to the lawnmower :-)
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Reviewed in the United States on January 1, 2025
L
Verified Purchase
Linda C.
Bozeman, US
★★★★★ 5
Will Last!!!
My Saban is a black lab/pittie mix and is a very aggressive chewer with the bulldog jaws. I had bought the large ball for him and to be honest I didn't think it would be as big as it is or as heavy 😂😂😂!!! It's made of a very durable plastic and is holding up extremely well to his chewing on it!!! I'll be honest and say that unless you're using it outside and have some really good muscles in your arm that I would recommend buying this in the smaller size!!!! I normally play with him inside with his toys when the weather isn't good for going outside, but I don't throw this one inside because #1 it's so heavy and big that I can't throw it very good and # if I was to play with it inside I'm afraid the weight of it would break something!!! I would say that this is a great quality and very durable, but I wouldn't buy the large one again!!! I would definitely recommend this brand in a smaller size ball 👌 😊😊
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Reviewed in the United States on October 11, 2023
C
Verified Purchase
Courtney
San Leandro, US
★★★★★ 4
Great product...wish you had color options
My dogs love these balls, but I wish you could choose the color. This is my dog's favorite toy. He can play tug of war with his siblings, and the ball usually lasts for quite awhile. Considering they are usually pretty destructive puppers, this is a minor miracle. But, I can't just pick his favorite color and get it delivered. I have to play roulette, and pray that his color is the one that I get when I open the box. If they can allow us to choose the color(s) that we want, then this review will be upgraded to 5 stars.
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Reviewed in the United States on December 17, 2023

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