SKU: 58761598467

PAPP-A Recombinant Rabbit mAb (SDT-226-46)

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Description

PAPP-A Recombinant Rabbit mAb (SDT-226-46)Product Specification Host Rabbit Antigen PAPP A Synonyms Pappalysin 1, IGFBP 4ase Immunogen Recombinant Protein Accession Q13219 Clone Number SDT 226 46 Antibody Type Rabbit mAb Reactivity Hu Purification Protein A Concentration 0. 25 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied Dilution application dilution species

Product Specification


Host Rabbit
Antigen PAPP-A
Synonyms Pappalysin-1, IGFBP-4ase
Immunogen Recombinant Protein
Accession Q13219
Clone Number SDT-226-46
Antibody Type Rabbit mAb
Reactivity Hu
Purification Protein A
Concentration 0.25 mg/ml
Physical Appearance Liquid
Storage Buffer PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
IHC-P 1:1000 null

Background

PAPP-A is a proteolytic enzyme that was discovered to increase local insulin-like growth factor (IGF) availability for receptor activation through cleavage of inhibitory IGF binding proteins (IGFBPs). Reduced IGF signaling has been associated with increased lifespan and healthspan.
Therefore, inhibition of PAPP-A represents a novel approach to indirectly decrease the availability of bioactive IGF [PMID: 28035757 IF: 8.0 Q1 ].

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Exchange/Return Notes
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SKU: 58761598467

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4.3 ★★★★★
Based on 2429 reviews
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Kelly S.
Belleville, US
★★★★★ 3
Not for aggressive chewers
Size: Medium Chew Stick, Style: Peanut Butter
Not for aggressive chewers. Our dog tore pieces off within minutes
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 15, 2026
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Verified Purchase
Kristy Moss
Lowell, US
★★★★★ 2
Not very strong
Size: Medium Chew Stick, Style: Peanut Butter
We have a different bone from this company that my dogs love and it’s been indestructible for my hard chewers, but NOT this one. Within 20min of chewing he was pulling pieces off. It’s not nearly as tough as the other one we have. Pretty disappointed.
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Reviewed in the United States on January 18, 2026
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Verified Purchase
Pat
Phoenix, US
★★★★★ 1
Recommended for Seniors, Not for Chewers
Size: Medium Chew Stick, Style: Pork Sausage
My 12lb dog loves Playology toys because of the long-lasting scent that's stimulating for her (even though I can't detect the smell). I got this toy because I wanted to add a different texture to her toy bin since most of her toys are rope & plush. Unfortunately, after only 10 minutes of playing with this toy, she managed to tear the pieces of the rubber off and I had to take it away so she doesn't choke on the pieces that were breaking off. Now I see why this toy's recommended for senior dogs. Definitely not recommended for active dogs or heavy chewers.
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Reviewed in the United States on July 27, 2024
A
Verified Purchase
Amanda
Lake Worth, US
★★★★★ 5
Very well made and helps clean teeth and mouth! Great for all age dogs!s!
Size: Medium Chew Stick, Style: Peanut Butter, Size: Medium Chew Stick, Style: Peanut Butter
My pup absolutely loves it and it's helping him with teething. It doesn't break off in a bunch of big pieces, just tiny pieces. He spits out the little pieces thankfully! Very well made and smells appetizing to dogs! It definitely helps clean his teeth & the rest of his mouth!
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Reviewed in the United States on April 6, 2025
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Whoknewit'sme
Los Angeles, US
★★★★★ 5
Mini Aussie LOVES
Flavor Name: Peanut Butter, Size: Large, Flavor Name: Peanut Butter, Size: Large
My little Meg loves these chew bones, she sneaks in and steals them from our Golden Retriever and our Great Pyrenees. She chews the orange covering off in minutes and the under bone lasts a few weeks. The dogs steal them from each other all the time, even though I buy them each one. Highly recommend if you have a super chewer, just be mindful the orange cover is easily chewed off.
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Reviewed in the United States on May 13, 2024

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