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Description
IgG1 Fc (NNAS) Protein, HumanProduct Specification Species Human Synonyms IgG1 Fc, Ig gamma 1 chain C region, IGHG1 Accession P01857 Amino Acid Sequence Thr21 Ile192 (S82N, T83A, Y84S) PKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNNASRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK Expression System HEK293 Molecular Weight 30 33kDa Purity >95% by
Product Specification
| Species | Human |
| Synonyms | IgG1 Fc, Ig gamma-1 chain C region, IGHG1 |
| Accession | P01857 |
| Amino Acid Sequence | Thr21-Ile192 (S82N, T83A, Y84S) PKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNNASRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 30-33kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
Immunoglobulin G (IgG) is one of the most abundant proteins in human serum, accounting for about 10–20% of plasma protein. Immunoglobulin G (IgG) is a monomer immunoglobulin, mainly involved in secondary antibody reaction, plasma B cell synthesis and secretion, constitute 75% of human serum immunoglobulin. There are four subtypes of human IgG antibodies: IgG1, IgG2, IgG3, IgG4; mice IgG can be divided into five subtypes; IgG1, IgG2A, IgG2B, IgG2C and IgG3; rats have four subtypes: IgG1, IgG2A, IgG2B and IgG2C. The nomenclature of IgG subtypes of different species is independent, so there is no correlation among different genera. The content of IgG1 in serum accounts for about 60%, and the half-life in serum is about 21 days. After pepsin cleavage, IgG1 is divided into two antigenic binding sites F (ab) s and a highly conserved Fc fragment, and Fc has a highly conserved N-glycosylation site. IgG1 is the most potential subtype in tumor immunotherapy. The active form of IgG1 is bivalent monomer, and human IgG1 can also bind to mouse Fc γ receptor, so the obvious effect can be observed in mouse model.
Shipping Notes
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Exchange/Return Notes
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4.1 ★★★★★
Based on 2463 reviews
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Product Reviews
★★★★★ 5
Great for night time play!
Size: One-Size-for-Most
This ball is great! It is a 2-for-one light up feature so we love the flashing lights and if she drops it in the snow after those lights stop, we can still find it because of the strong glow that gets its charge from the flashing LED lights. Our first one lasted a few years, we lost it on a trip so now back for our second one so we can keep the night time fetch going! She is a golden retriever for size reference. Any bigger of a breed and I would worry it might be too small for her mouth. It’s a bit smaller than a tennis ball. Just don’t make the same mistake I did and let them have it in the house at night, she walked up to my bedside while I was asleep one night and squeezed it to activate it. Those lights are so bright it was a rude awakening!
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Reviewed in the United States on November 11, 2025
★★★★★ 4
Good option for playing at night
Size: One-Size-for-Most
This ball is a good option if your dog likes to fetch at night. It stays lit for about 20 minutes or so, but that is me only leaving it out of the counter, being "charged" by whatever house lights are on. My dog isn't a big chewer, but it seems as though it would hold up well. I like that it is easy to rinse and clean. It seems to be a good value.
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Reviewed in the United States on January 16, 2026
★★★★★ 5
Night play
Size: One-Size-for-Most
My dog like many other dogs loves to play. We needed a ball that fit into the handheld thrower we had but something that we could find it at night. This has been wonderful!
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Reviewed in the United States on April 26, 2026
★★★★★ 1
It stopped working after three play sessions
Size: One-Size-for-Most
I thought this ball was great until a week later it stopped blinking and got lost in the snow. We only played with it for three days for 20 minutes at a time. It should’ve lasted a lot longer.
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Reviewed in the United States on December 12, 2025
★★★★★ 5
It’s absolutely perfect for fetch in the dark!
Size: One-Size-for-Most
We needed to find a glow in the dark ball to run our over active dog after dark ( gets dark now about 5 pm ish) I was hesitant to buy this ball at first. We went to try it out and it totally blew my expectations! The ball really glows, it’s a durable rubber and when it hits the ground it lights up blue and red. Incredibly satisfied and just ordered 2 more. If you need to run your dog in the dark, this is absolutely for you. Highly recommend it
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Reviewed in the United States on December 5, 2025