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Description
Fc γ RIIA/CD32a His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms Low affinity immunoglobulin gamma Fc region receptor II a, IgG Fc receptor II a, CDw32, Fc gamma RII a, Fc gamma RIIa, FcRII a, CD32, FCGR2A, FCG2, FCGR2A1, IGFR2 Accession Q8SPW4 1 Amino Acid Sequence Gln28 Pro208, with C terminal His Expression System HEK293 Molecular Weight 30 35kDa(Reducing) Purity 95%, by SDS PAGE under reducing conditions Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag
Product Specification
| Species | Cynomolgus |
| Synonyms | Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, CDw32, Fc-gamma RII-a, Fc-gamma-RIIa, FcRII-a, CD32, FCGR2A, FCG2, FCGR2A1, IGFR2 |
| Accession | Q8SPW4-1 |
| Amino Acid Sequence | Gln28-Pro208, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 30-35kDa(Reducing) |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs is identified as three subtypes: RI (CD64), RII (CD32) and RIII (CD16). There are three human Fc γ RII / CD32 genes (A, B and C), two crab eating monkeys (An and B), and one Fc γ RII B in mice. Fc γ RIIA of cynomolgus monkey consists of extracellular domain, transmembrane domain and cytoplasmic domain. The extracellular domain includes two IgG domains. The Fc γ RIIA protein of crab-eating monkey has 89% homology with human Fc γ RIIA. CD32a is expressed in a variety of immune cells such as macrophages, neutrophils and platelets. When it binds to ligands, it initiates inflammatory responses, including cytolysis, phagocytosis, degranulation and production of cytokines. This response can be regulated by co-expression of inhibitory receptors such as CD32B.
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