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Description
Human GZMB , His tagProduct Specification Species Human Synonyms C11, CTLA 1, Cathepsin G like 1 (CTSGL1), Cytotoxic T lymphocyte proteinase 2 (Lymphocyte protease), Fragmentin 2, Granzyme 2, Human lymphocyte protein (HLP), SECT, T cell serine protease 1 3E, CGL1, CSPB, GRB Accession P10144 Amino Acid Sequence Protein sequence(P10144, Gly19 Tyr247, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | C11, CTLA-1, Cathepsin G-like 1 (CTSGL1), Cytotoxic T-lymphocyte proteinase 2 (Lymphocyte protease), Fragmentin-2, Granzyme-2, Human lymphocyte protein (HLP), SECT, T-cell serine protease 1-3E, CGL1, CSPB, GRB |
| Accession | P10144 |
| Amino Acid Sequence | Protein sequence(P10144, Gly19-Tyr247, with C-10*His) GEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKTMKRYGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:27.4kDa Actual:33kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, 1mM EDTA, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Granzyme B (GZMB) is one of the serine protease granzymes most commonly found in the granules of natural killer cells (NK cells) and cytotoxic T cells. It is secreted by these cells along with the pore forming protein perforin to mediate apoptosis in target cells.Granzyme B has also been found to be produced by a wide range of non-cytotoxic cells ranging from basophils and mast cells to smooth muscle cells. The secondary functions of granzyme B are also numerous. Granzyme B has shown to be involved in inducing inflammation by stimulating cytokine release and is also involved in extracellular matrix remodelling.
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4.8 ★★★★★
Based on 1390 reviews
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Product Reviews
★★★★★ 5
Worth the Price!
Size: 8.5 Wide, Color: Brown
It’s really worth my money for this shoes.
The style & quality look good!
Fitting is perfect & true to size.
I’m satisfied w/ my purchase.
Many thanks, Amazon.
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Reviewed in the United States on December 15, 2025
★★★★★ 4
7 months after purchase
Size: 8.5 Wide, Color: Black
7 months after purchase. Still look good. Very comfortable right out of box. Outside edges of heels chipped away almost right away. Never seen that before. Brittle/ bad choice of rubber or design? Leather upper still looks pretty good with a little polish. Rubber soles wearing very well.
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Reviewed in the United States on May 6, 2025
★★★★★ 5
Good quality and beautifull
Size: 10, Color: Cognac
i never put an revieuw. but i cam here to leave my revieuw for shis shoe. Florsheim Men's, Rucci Plain Toe Chukka Boot is the best Floesheim shoe i ever had, i was afraid to buy it because i life in south amarica en its expensive. but it amazing, very soft inside and true size. i would defenitly buy an black on. and it not heavy, feels light on the feet. i hope you will have the same experience.
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Reviewed in the United States on June 1, 2026
★★★★★ 5
Buy 1/2 size down
Size: 11, Color: Black
Great, nice cushion, sleek design, heel looks really durable
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Reviewed in the United States on September 14, 2025
★★★★★ 5
Espectacular
Size: 8.5, Color: Cognac
Excelentes zapatos súper bonitos y color perfecto
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Reviewed in the United States on April 9, 2026