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Description
α-Actinin-1 Recombinant Rabbit mAb (SDT-311-20)Product Specification Host Rabbit Antigen Actinin 1 Synonyms Alpha actinin 1, ACTN1 Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Cell membrane Accession P12814 Clone Number SDT 311 20 Antibody Type Rabbit mAb Application WB, IHC P Reactivity Hu, Ms, Rt Predicted Reactivity Bv, Mq Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability &
Product Specification
| Host | Rabbit |
| Antigen | α-Actinin-1 |
| Synonyms | Alpha-actinin-1, ACTN1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Cell membrane |
| Accession | P12814 |
| Clone Number | SDT-311-20 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Bv, Mq |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied. |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | |
| IHC-P | 1:2000 |
Background
Alpha-actinin (α-actinin) is a ubiquitous cytoskeletal protein, which belongs to the superfamily of filamentous actin (F-actin) crosslinking proteins. It is present in multiple subcellular regions of both muscle and non-muscle cells, including cell-cell and cell-matrix contact sites, cellular protrusions and stress fiber dense regions and thus, it seems to bear multiple important roles in the cell by linking the cytoskeleton to many different transmembrane proteins in a variety of junctions. Four isoforms of human α-actinin have already been identified namely, the "muscles" α-actinin-2 and α-actinin-3 and the "non-muscles" α-actinin-1 and α-actinin-4 [PMID: 21241830]. α-actinin-1 is an important intracellular calcium-sensing protein, the major actin crosslinking protein in focal adhesions and stress fibers [PMID: 27272015].
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