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Description
Alexa Fluor® 488 Mouse Anti-Human CD28 Antibody (15E8)Product Specification Host Mouse Antigen CD28 Synonyms TP44 Immunogen N A Location Membrane Accession P10747 Clone Number 15E8 Antibody Type Recombinant mAb Isotype IgG1,k Application FCM Reactivity Hu Purification Protein G Concentration 0. 2mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 0. 1% BSA, 0. 01% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied. Dilution
Product Specification
| Host | Mouse |
| Antigen | CD28 |
| Synonyms | TP44 |
| Immunogen | N/A |
| Location | Membrane |
| Accession | P10747 |
| Clone Number | 15E8 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 0.2mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 0.1% BSA, 0.01% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume |
Background
CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular). CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen-presenting cells (APCs). The CD86 expression on antigen-presenting cells is constitutive (expression is independent of environmental factors). It is generally reported, that CD28 is expressed on 50% of CD8+ T cells and more than 80% CD4+ T cells in human, but during the course of activation some T cells lose this molecule. In general, CD28 is a primary costimulatory molecule for T cell activation.
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