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Description
Tie-2 His Tag Protein, HumanProduct Specification Species Human Synonyms TIE2, Tie 2, TEK, VMCM, VMCM1, CD202b, Angiopoietin 1 receptor Accession Q02763 Amino Acid Sequence Ala23 Leu748, with C terminal 10*His
Product Specification
| Species | Human |
| Synonyms | TIE2, Tie-2, TEK, VMCM, VMCM1, CD202b, Angiopoietin-1 receptor |
| Accession | Q02763 |
| Amino Acid Sequence | Ala23-Leu748, with C-terminal 10*His AMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIQRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 95-110kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Jones N. et al. (1998) The Tek / Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene. 17(9): 1097-1108. 2、Sato A. et al. (1998) Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. Int Immunol. 10(8): 1217-1227. |
Background
Tie-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.7 ★★★★★
Based on 935 reviews
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Product Reviews
★★★★★ 5
Quick and easy
My water kettle just stopped working after a year. Once I boxed up and returned the kettle, Asurion refunded my account.
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Reviewed in the United States on May 8, 2026
★★★★★ 5
Easy peasy
Good communication. Easy to file a claim. Received my refund as soon as the product was mailed.
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Reviewed in the United States on May 21, 2026
★★★★★ 4
Its good to have for electronics and kitchen items
I get the Insurance for certain Electronics and kitchen items.
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Reviewed in the United States on April 17, 2026
★★★★★ 5
Worth the money.
Quick and easy claim process. My refund was processed the same day that I shipped back the product.
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Reviewed in the United States on April 13, 2026
★★★★★ 1
All Gotchas, Gimmicks, and Grief
My husband broke the item in question, which was a Chemex coffee maker made of nothing but glass. It shattered full of coffee, so like a normal human he cleaned up the dangerous mess and threw it away. I put in a claim, and it said that I had to ship back the product. Believing that the Asurion process was as simple as stated, and reading the agreement that does mention that sometimes they'll require shipment of the item, but that they will review cases and use reasonable judgment, I contacted their chat, explaining that the requirement that I mail them a wet pile of shards of glass soaked in coffee (and a little bit of blood) was unsafe and unreasonable. I don't even know how I could do that in a way that would be safe for the people opening the packaging, or even to take it to the store. The shards of glass might puncture any plastic, and the wetness would soak through, plus there's the biohazard issue. Seems silly for a $47 product replacement to me. I figured any human would understand.
First chat associate closed my case without even responding to me. I had to reopen it.
The second one told me, "Yes, that is how your warranty works" as an answer to my "Hello, the last chat closed without me talking to anyone." I tried to explain the situation, and was told "If you call the hotline, maybe they'll help you."
I call the hotline. The first person tells me tough, I have to mail it. I say it was thrown away. He says "AHA then it's lost! Your warranty doesn't cover lost things!" I say no, it's not lost, it was disposed of properly as shards of glass should be. I finally ask can I speak to someone else or a supervisor. He lies and says yes. I sit on hold for 20 minutes, never any wait time or any sort of indicator of when someone will talk to me. The phone call quality finally gets very horribly staticky, so I hang up and try again.
Hallelujah, I get a decent human being who immediately says, "Oh, no, that's not reasonable! That is an unsafe thing to have to mail. I'll send it to the override department who should approve this because it's obvious that's not a normal thing to expect."
Today I get an email that says:
We can't approve your claim.
We reviewed your NO SUPPORTING MANUFACTURER COFFEE MAKER claim.
The product in your claim is not covered by your plan.
As a result, we're unable to approve your claim.
Nothing about the requirement to mail a biohazard, just the item isn't covered even though the item is absolutely covered.
While I understand that loss prevention is important, this is a very small potatoes return and it isn't like I made this up. It would be easy to make me happy. I'm sure it has cost them more money to deny it than they would have lost covering the Chemex. I've bought multiple of their product replacement policies before. I never will again. They didn't offer for me to send a picture or anything. They just wasted hours of my time and sent a clearly AI-based answer, rather than treating me like a valuable customer.
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Reviewed in the United States on February 28, 2024