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Description
Her4 His Tag Protein, HumanProduct Specification Species Human Synonyms Her4, ERBB4, 4ICD, MGC138404, p180erbB4 Accession Q15303 Amino Acid Sequence Gln26 Pro651, with C terminal 10*His
Product Specification
| Species | Human |
| Synonyms | Her4, ERBB4, 4ICD, MGC138404, p180erbB4 |
| Accession | Q15303 |
| Amino Acid Sequence | Gln26-Pro651, with C-terminal 10*His QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 87-101kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Segers V F M. et al. (2020) The role of ErbB4 in cancer. Cell Oncol. 43: 335-352. 2、Xu J. et al. (2018) ERBB4 promotes the proliferation of gastric cancer cells via the PI3K/Akt signaling pathway. Oncol Rep 39: 2892-2898. |
Background
HER4, also known as ErbB4, is a member of epidermal growth factor receptor (EGFR) or ErbB family. The HER4 gene is localized on chromosome 2q33.3–34. HER4 is necessary for normal development of body systems including heart, nervous system, and mammary gland. HER4 is commonly expressed in many human tissues, both adult and fetal. EGFR/ErbB1/HER1, ErbB2/HER2, ErbB3/HER3, and ErbB4/HER4 are members of this receptor tyrosine kinase family. HER4 is the only member of this family of receptors with growth inhibiting properties. HER4 can activate related genes in the nucleus when combined with epidermal growth factor (EGF), promoting cell division and proliferation. It is activated through ligand binding and activates MAPKs and PI3K/AKT pathways. Her4 promotes glycolysis, glutaminolysis, mitochondrial biogenesis & OXPHOS through c-Myc-dependent signaling axis in cancer. The Her4-mediated metabolic reprogramming may in part cooperate to promote tumorigenesis in certain cancers.
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4.5 ★★★★★
Based on 2113 reviews
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Product Reviews
★★★★★ 5
Go for it if it is within your budget
Assembly instructions are easy to follow and the body is sturdy. Value for money
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Reviewed in the United States on March 12, 2026
★★★★★ 4
Perfect for small spaces
Color: Black & Espresso, Color: Black & Espresso
I do like this table. The directions are less than desirable. I have put together MANY pieces of furniture.
I put this entire thing together and realized at the end that I had some pieces backwards so the top would not collapse back to coffee table. Luckily when I took it back apart, I did not damage it beyond repair.
It looks great and perfect size for my apartment livingroom. Great option to be able to use as a dining table on the rare occasion I need one. Price was right and it is pretty sturdy. Extra storage underneath for books and such.
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Reviewed in the United States on December 25, 2025
★★★★★ 5
Awesome
Color: Black
Wonderful coffee table. Easy to assemble. Very durable, even when the table is fully folded out. Any little touch will leave fingerprints though, so be prepared to clean it a bunch
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Reviewed in the United States on December 13, 2025
★★★★★ 5
Cute and easy to use!
It came quickly and the directions were easy to follow! I will say that we used our electric screwdriver instead of the one provided just for when you’re screwing in the hinges— the one they provided was like dull and hard to use for that. But other than that it was seamless putting together.
We use it almost everyday for kids schoolwork. I love storing their school books underneath as well. It’s lightweight enough that my kids (6 &7) can set up and put down the table themselves and it’s sturdy when using the full table or the pull up half table. Highly recommend!
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Reviewed in the United States on September 18, 2024
★★★★★ 5
Great value
Perfect size, great quality and looks great!
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Reviewed in the United States on November 16, 2025