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Description
Stathmin 1 Recombinant Rabbit mAb (SDT-383-4)Product Specification Host Rabbit Antigen Stathmin 1 Synonyms Stathmin, Leukemia associated phosphoprotein p18, Metablastin, Op18, pp19, Prosolin, Protein Pr22, pp17, C1orf215, LAP18 Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton Accession P16949 Clone Number SDT 383 4 Antibody Type Recombinant mAb Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | Stathmin 1 |
| Synonyms | Stathmin, Leukemia-associated phosphoprotein p18, Metablastin, Op18, pp19, Prosolin, Protein Pr22, pp17, C1orf215, LAP18 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton |
| Accession | P16949 |
| Clone Number | SDT-383-4 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:2000 | |
| ICC | 1:2000 | |
| ICFCM | 1:500 |
Background
Stathmin 1 (STMN1), also known as p17, p18, p19, 19K, metablastin, oncoprotein 18, LAP 18 and Op18, is a 19 kDa cytosolic protein. It was the first discovered member of a family of phylogenetically related microtubule-destabilizing phosphoproteins critically involved in the construction and function of the mitotic spindle. A threshold level of STMN1 is required for orderly progression through mitosis in a variety of cell types. STMN1 is overexpressed across a broad range of human malignancies (leukemia, lymphoma, neuroblastoma; ovarian, prostatic, breast and lung cancers and mesothelioma). It is also upregulated in normally proliferating cell lines but is only rarely upregulated in nonproliferating cell lines with the exception of neurons, anterior pituitary cells and glial cells [PMID: 18759697].
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