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Description
IL-4R alpha/CD124 His Tag Protein, MouseProduct Specification Species Mouse Synonyms IL 4R alpha, CD124, IL4R, IL4RA Accession P16382 Amino Acid Sequence Ile26 Arg233, with C terminal 8*His IKVLGEPTCFSDYIRTSTCEWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRYQMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPSNNLLYKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTARVRVRSQILTGTWSEWSPSITWYNHFQLPLIQRGGGSHHHHHHHH Expression System HEK293 Molecular Weight 35 45kDa Purity >95% by SDS PAGE Endotoxin
Product Specification
| Species | Mouse |
| Synonyms | IL-4R alpha, CD124, IL4R, IL4RA |
| Accession | P16382 |
| Amino Acid Sequence | Ile26-Arg233, with C-terminal 8*His IKVLGEPTCFSDYIRTSTCEWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRYQMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPSNNLLYKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTARVRVRSQILTGTWSEWSPSITWYNHFQLPLIQRGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 35-45kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Nelms K. et al. (2003) The IL-4 receptor: signaling mechanisms and biologic functions. Annual Review of Immunology. 17: 701-738. |
Background
IL-4Rα is a member of the hematopoietin receptor superfamily. Among the defining features of the members of this superfamily of receptors are shared structural motifs in the extracellular region, which consists of type III fibronectin domains. These motifs include conserved paired Cys residues and, in the membrane proximal region, a WSXWS motif. The latter has been proposed to be required for maintaining the receptor in a conformation favorable to cytokine binding. Structural alterations in the IL-4Rα extracellular region may result in altered receptor signaling capabilities. Indeed, a variant of the human IL-4Rα chain containing a Ile50Val substitution was isolated from atopic individuals and has been shown to enhance signal transduction resulting in the increased production of IgE.
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4.3 ★★★★★
Based on 1608 reviews
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Product Reviews
★★★★★ 5
Everything I wanted
Size: 7, Color: Bison Brown
Fantastic! So comfortable and cute. I usually wear a 7.5 or 8 but followed comments and ordered size 7. They fit perfectly.
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Reviewed in the United States on June 8, 2026
★★★★★ 5
Comfort
The best summer foot wear. These sandals are built for comfort with a great foot bed that leaves your feet feeling great at the end of the day.
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Reviewed in the United States on May 25, 2026
★★★★★ 5
Best shoe ever
5 star rating for literally the best shoe ever. I wore these almost everyday this summer. They are so incredibly comfortable. Cushion and padding is wonderful makes walking and wearing them very easy. They are not to platform at all and they don't have a separate heel height from the rest of the shoe so you're on a even walking ground. Size is perfect I stayed true to size and ordered my original sizing in Ugg which is perfect. The style os so trendy and literally goes with everything. I highly suggest them. I have back problems/ back surgery and these made my life so much easier. Comfortable and great support.
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Reviewed in the United States on October 16, 2025
★★★★★ 5
Well made sandals
Nice sandal that works well for me, feet sit comfortably in the shoes. I’m a quadriplegic that needs someone to wrestle my legs while putting my shoes on for me. These go on fairly easily. I have short legs and the extra height of the sandals helps to reduce the pressure on the back of my legs while my feet are on the legrests. Also my ankles tend to buckle and cause my feet and shoes to roll over onto the side of my foot. The soles of the UGG Goldenglow are wide and flat, substantially reducing this tendency. As far as comfort and function while walking, I can’t speak to that.
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Reviewed in the United States on February 25, 2026
★★★★★ 5
So comfortable but only lasted 5 months…
Size: 9, Color: Sea Salt, Size: 9, Color: Sea Salt
I was hesitant to buy these without being able to try them on, but I’m so glad I did! They are incredibly comfortable. I am on my feet for a large portion of the day as a school principal and these feel amazing all day. They’re very adjustable so if you have feet that swell (or just fatter feet like me) these should be able to accommodate you. They are clunky but really cute! They’re also easy to clean. I’ve worn mine just about every day since I received them and can easily wipe them down with a wet paper towel to make them look new. They will occasionally trip you up if you’re not careful, the same way Ugg boots can do, but that hasn’t been a big problem for me. They’re very lightweight and versatile. Love them!
Update: I probably just wore these too hard because today I was walking the school hallway and the shoe just snapped. One of the sides was completely unattached and within 30 minutes they were only on my foot by one strap. Super disappointed!! But I loved them enough that I ordered another pair to get me through until boot weather.
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Reviewed in the United States on June 2, 2024