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Description
IL-2R beta/CD122 His Tag Protein, HumanProduct Specification Species Human Antigen IL 2R beta CD122 Synonyms IL 2R beta, CD122, IL2RB, RP5 1170K4. 6, P70 75 Accession P14784 Amino Acid Sequence Ala27 Asp239, with C terminal 8*His AVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSHHHHHHHH Expression System HEK293 Molecular
Product Specification
| Species | Human |
| Antigen | IL-2R beta/CD122 |
| Synonyms | IL-2R beta, CD122, IL2RB, RP5-1170K4.6, P70-75 |
| Accession | P14784 |
| Amino Acid Sequence | Ala27-Asp239, with C-terminal 8*His AVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 36-42kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Foss F. (2006) Clinical experience with denileukin diftitox (ONTAK). Semin Oncol. 33(1 Suppl 3): 11-6. 2、Sprent J. et al. (2001) T cell death and memory. Science. 293(5528): 245-248. |
Background
Interleukin-2 receptor (IL-2R), as the specific receptor of interleukin-2(IL-2), perform their biological functions by binding with IL-2 to transmit signals into cells insides, which induced the downstream signal expression and participated in immune response. The longest IL-2R beta (IL-2Rβ) in the intracellular region has many binding sites for protein phosphorylation. Therefore, IL-2Rβ plays an indispensable role in signal transduction due to its sequence and structural characteristics. IL-2R mediates the multipotency of IL-2 on AC lymphocytes including T cells, B cells and NK cells. The combination of IL-2 and IL-2R complex can cause intracellular signal events and ultimately lead to cell proliferation. In addition, dysregulated expression of the IL-2Rβ abrogates development of NK cells. What’s more important is that T cell proliferation and development of IFNc-producing effector CD8+ T cells depend upon IL-2Rβ.
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